Authors:
Fokor Uddin
, Md. Anwar Hossain
, Razib Das
, Md. Matiur Rahman, Salah Uddin Ahmad
,
Md. Rashedunnabi Akanda and Md. Siddiqul Islam
|
Abstract:
The present study was undertaken to evaluate the toxic effects of leaves of Datura stramonium in
rats during the period of March to April 2012. Twenty rats were randomly divided in to four
equal groups (n=4) and marked as T0, T1, T2, and T3. Rats of group T0 were given normal feed
and water and kept as control group. Rats of group T1, T2, and T3 were fed with recommended
feed and drink water treated with paste of whole leaves of datura @ 50,100 & 200mg/kg body
weight respectively. Body weight and hemato bio-chemical parameters were recorded at every
14 days intervals. Rats of group T3were apparently normal up to first week. From second weeks
of treatment feed consumptions was reduced showing indigestion, anxiety, fatigue, muscular
tremor, ataxia, loss of muscle coordination and ruffled hair coat. Rats of group T1 and rats of
group T2 showed mild toxic symptoms. The mean body weight of rats of group T3 was
significantly (P<0.01) reduced. In group T3 total erythrocyte count and hemoglobin content were
significantly (P<0.01) reduced on day 14 and 28 but in other groups not reduced significantly
(P<0.05). The activities of SGPT, SGOT and ALP were elevated in all treated groups than
control groups but in group T3, the elevation of SGPT, SGOT and ALP were significantly higher
than that of group T1 and T2. The toxic effect of Datura stramonium in rats is dependent on
duration of treatment and dose. |
